in EU
On 7–9 November 2025 in Tokyo, at the Hideoki Ogawa Auditorium, Juntendo University, the 5th Annual Conference of the International Society for Hydrogen Medicine and Biology (ISHMB) will be held together with the 14th Conference of the Japanese Biomedical Society for Molecular Hydrogen. The forum will bring together researchers, clinicians, and engineers to discuss the fundamental mechanisms of action of molecular hydrogen (H₂), clinical protocols, and new devices for its generation and delivery.
Motoaki Sano (Japan, Yamaguchi University)
Motoaki Sano, MD, PhD — cardiologist and translational medicine researcher. A leading figure in inhaled molecular hydrogen (H₂) therapy for ischemia–reperfusion injury, post–cardiac arrest syndrome, and cardiovascular conditions.
His talk focuses on the control of ischemia–reperfusion injury via H₂ inhalation. Sano’s team demonstrated reduced myocardial damage in preclinical models (rats, dogs), followed by the first clinical protocol of inhalation in acute myocardial infarction patients. A separate section covers results of a multicenter randomized trial in post–cardiac arrest patients, where H₂ is treated as a medical gas. An important part of the lecture addresses pharmacokinetics: how hydrogen behaves in the body via different administration routes (inhalation, H₂-rich water, hydrogen baths, intravenous solutions) and what this implies for dosing and safety.
Qianjun He (Shanghai Jiao Tong University, China)
Qianjun He, PhD — Professor at the School of Materials Science and Engineering, Shanghai Jiao Tong University (SJTU); Director of the R&D Center at SJTU Shenzhen Research Institute; previously Professor at Shenzhen University; Marie Curie fellowship at the University of Leeds. His overall focus is “smart” nanomaterials and nanomedicine for precision gas therapy (including H₂), with a scientific emphasis on engineering carriers that deliver therapeutic gases (H₂, NO, CO, H₂S, CH₄) to lesions with controlled release, targeting, and combination with other modalities (e.g., photo/sonocatalysis). This is the core of nanomaterials-mediated gas therapy, where H₂ is viewed as a gentle anti-inflammatory and antioxidant module. He has authored 100+ papers in top-quartile journals (Science Advances, Nature Communications, Advanced Materials, etc.); h-index ~60+; recognized as a Highly Cited Researcher and in the Top 2% of scientists by career impact.
His lecture topic is “Hydrogen-medicine materials” for tissue engineering: nanomaterials and magnesium platforms that generate H₂ locally in tissues, thereby gently reducing inflammation and oxidative stress.
Michal Botek (Palacký University, Czech Republic)
Michal Botek, PhD — Associate Professor at the Faculty of Physical Culture, Palacký University (Olomouc, Czech Republic), specializing in exercise physiology, heart rate variability (HRV) monitoring, load diagnostics, and recovery in athletes and patients. Botek’s team has studied H₂ effects for many years on fatigue, recovery, lactate, markers of muscle damage, and HRV. The talk also examines inter-individual variability in response: training status, age, and the choice of form and timing (inhalation, water, pre/post exercise).
Shen Wenbiao (Nanjing Agricultural University, China)
Shen Wenbiao — Professor of Biochemistry and Molecular Biology at the College of Life Sciences, Nanjing Agricultural University (NAU, China). Founder and head of the Gasotransmitter Research Group, an interdisciplinary team studying the roles of small gaseous molecules (including H₂) in plant and animal physiology. He investigates molecular hydrogen as a signaling molecule in plants: stress tolerance, growth, and post-harvest preservation (“hydrogen agriculture”), linking field protocols to molecular mechanisms (ROS/redox, hormonal pathways). In 2025, he advances the idea of universal H₂ production in eukaryotes, bridging agri-biology and biomedicine.
His talk covers agricultural applications of hydrogen: how H₂ helps plants withstand stress and extend shelf life. He presents “field-to-lab” results — from field treatments to cellular defense mechanisms — discusses fresh data on potential universality of H₂ metabolism in eukaryotes, and outlines practical schemes for the agri- and food sectors.
Shigeo Ohta (Nippon / Juntendo, Japan)
Shigeo Ohta — Distinguished Professor at Nippon Medical School and Visiting Professor at Juntendo University (Tokyo, Japan), one of the pioneers of hydrogen medicine; co-founder of ISHMB and Honorary President of JBMSH2/ISHMB. His work laid the foundation for the field: in 2007, Ohta’s team showed that molecular hydrogen (H₂) selectively neutralizes the most reactive radicals and mitigates ischemia–reperfusion injury; subsequent reviews expanded the understanding of H₂ as a regulator of redox signaling and inflammation. Current interests include neuroprotection, including cognitive impairment and Alzheimer’s disease.
His lecture is an educational overview of the evolution and future mission of hydrogen medicine and biology: from the seminal 2007 publication to contemporary clinical protocols (resuscitation, cardiovascular and neurological indications), standardizing dosing and device quality; emphasis on mechanisms (redox/inflammation), convincing clinical endpoints, and building a bridge between academia and industry.
Sponsored & Invited Talks
The program includes clinical case studies of combined immunotherapy with H₂ inhalation in stage IV cancer patients; experience with H₂ therapy in dialysis; practical questions of inhalation dosimetry (FiH₂, dose and exposure calculation). Invited lectures address chronic pain and comorbid mental conditions, regulatory status of delivery devices, and cardiovascular indications.
Who Will Benefit
- Physicians & Researchers — mechanisms of H₂ action, clinical trial design and outcomes, standardization of endpoints.
- Engineers & Manufacturers — requirements for medical devices and instruments for water/gas-mixture hydrogenation, quality control methods.
- Sports & Rehabilitation Specialists — recovery protocols, objective biomarkers of effect (HRV, lactate, damage markers).
- Agri- & Food Sector — crop treatment practices and technologies for extending freshness.
